Zoetis — Lutalyse Injection (Rx)

LUTALYSE 100 ML RX
$63.99
Please note that this item requires a veterinarian's prescription.

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Size : 100 ml
By Prescription Only
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Vaccine and Rx items are not returnable.

About This Product

Zoetis
SKU123456008414
BrandZoetis
Each ml contains 5 mg dinoprost.

 
USES

Horses:
Lutalyse is indicated for its luteolytic effect on corpora lutea in mares to “induce” estrus and may be utilized to stimulate regression of the corpus luteum followed by return to estrus and/or ovulation in mares demonstrating extended diestrus.
Cattle:
Lutalyse is indicated for its luteolytic effect in cattle. This luteolytic action may be utilized to:
  1. Effectively control the time of estrus in cycling cattle that have a corpus luteum
  2. Treat sub-estrus (no visible estrus)
  3. Induce abortion in cattle from 5 to 130 days of gestation
  4. Treat chronic metritis and pyometra
  5. Induce parturition on or after day 270 of gestation
  6. Use with FACTREL® (gonadorelin hydrochloride) sterile solution to synchronize estrous cycles to allow fixed-time artificial insemination (FTAI) in lactating dairy cows
Swine:
Lutalyse may be used to induce parturition in swine when administered within 3 days (72 hours) of normal predicted farrowing dates.

Manufacturer Label
Safety Data Sheet (SDS)

DOSAGE & ADMINISTRATION

Horses:
To induce estrus, administer 5 mg (1 mL) subcutaneously. See label for complete instructions.
Cattle:
To control estrus, to treat subestrus, pyometra, and mummified fetus and to induce abortion or parturition administer 25 mg (5 mL) intramuscularly.

  1. Effectively control the time of estrus in cycling cattle that have a corpus luteum: Cows and heifers treated during this time will return to estrus and ovulate within 2 or 4 days after treatment. (Note: administration of Lutalyse to cattle within 5 days after estrus or 4 days before the onset of the next estrus may not influence the timing of the next estrus.) Rectal palpations and good records of estrus cycles are helpful for the most efficient use of Lutalyse.
  2. Treat sub-estrus (no visible estrus): Individual cattle may have normal cyclical ovarian activity without detectable behavioral estrus; this occurs most frequently in the winter months, at peak lactation in high producing dairy cows, in cows receiving marginal nutrition and in suckled beef cows. If a corpus luteum is present and ovulation has not occurred in the previous 4 days, administration of Lutalyse may result in corpus luteum regression followed by return to estrus and ovulation. Breeding of cattle treated with PGF2α for the above indication may be by natural service, artificial insemination at the usual time in relation to observed estrus, or by fixed time insemination 78 hours (75-80 hours) post-treatment.
  3. Induce abortion in cattle from 5 to 130 days of gestation: Up to day 70, abortion usually occurs in less than 4 days; between days 70 and 130 in less than 7 days, but beyond day 130 less than 60 percent may abort within 3 weeks. Injected heifers should be kept under surveillance and given assistance if necessary.
  4. To treat chronic metritis and pyometra: In the cow, chronic metritis frequently occurs as a sequel to an acute or sub-acute endometritis in the first 2 or 3 weeks postpartum; typically, there is an intermittent purulent or muco-purulent discharge. Pyometra is characterized by the retention of purulent fluid within the uterus. Luteal regression through the administration of Lutalyse is followed by estrus, during which the uterus is evacuated and the uterine environment is relatively unfavorable to the bacteria involved in the infection. Treatment may have to be repeated after 10-12 days where the condition is longstanding.
  5. To induce parturition on or after day 270 of gestation: The interval from administration to parturition is 1 to 8 days (average 50-60 hours). Induction of parturition in cattle is indicated where there is risk of oversize calves or where early parturition is desired. In addition, induction is indicated where it is desired to terminate pregnancy complicated by miscellaneous conditions, such as mummified or macerated fetuses, hydrops amnii, hydroallantois, etc. Such fetuses may need manual help to complete their passage through the genital tract.
For use with FACTREL (gonadorelin hydrochloride) sterile solution to synchronize estrous cycles to allow fixed-time artificial insemination (FTAI) in lactating dairy cows: Administer 2 mL FACTREL Injection (100 mcg gonadorelin) per cow as an intramuscular injection in a treatment regimen as detailed in the label.

Swine:
To induce parturition administer 10 mg (2 mL) intramuscularly.See label for complete instructions.

CONTRAINDICATIONS & WARNINGS

Contraindications:
For subcutaneous use only in the equine and intramuscular use only in the bovine and porcine. Do not administer intravenously.
Cautions:
  1. PGF2α may produce abortion in pregnant mares, cows and sows.
  2. Since studies have not been conducted in horses suffering from acute and chronic respiratory diseases, PGF2α should be used with caution in such cases.
  3. Due to seasonally polyestrus nature of mares the efficacy of this drug will vary with the time of year it is administered.
  4. In cattle, PGF2α is ineffective when administered prior to day 5 after ovulation or within 4 days before the on-set of the next estrus.
  5. Parturition induction in swine earlier than 72 hours prior to the normal farrowing date may result in piglet mortality
Warnings:
Not for human use. Treated cattle and swine must not be slaughtered for use in food for at least 2 days after the latest treatment with this drug. Treated cattle must not be slaughtered for use in food for at least 7 days after sequential use with FACTREL.
No milk withholding time is required when used according to the label. This drug is not to be administered to horses that are to be slaughtered for use in food. This product should be handled carefully to avoid accidental self-injection or contact with the skin or mucous membranes of the user.
Prostaglandins of the F2α type may readily be absorbed through the skin and may cause bronchospasms and/or miscarriage. Pregnant women, women in childbearing age, asthmatics and people with other respiratory tract diseases should exercise extreme caution when handling this product such as wearing waterproof gloves. Accidental spillage on the skin should be washed off immediately with water.
In case of accidental self-injection, seek medical advice and show the package insert to the doctor. Should respiratory distress result from accidental inhalation or injection, the inhalation of a rapidly acting bronchodilator is indicated. Keep out of reach of children.

PHARMACEUTICAL PRECAUTIONS

Store between 15 and 25°C. Particulate matter, usually identified as silica flakes may appear after periods of storage. These particles have altered neither the potency nor sterility of Lutalyse Sterile Solution.